Recombinant Human CORT protein (rFc Tag)

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• Recombinant Human CORT protein (rFc Tag) (Eg4060)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg4060

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Validation Data Gallery

• 

  Purity of Recombinant Human CORT was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human CORT protein Gln77-Lys105 (Accession# O00230) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 1325
• Accession: O00230
• PredictedSize: 29.7 kDa
• SDS-PAGE: 32-38 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Cortistatin (CORT) is a multifunctional neuropeptide that inhibits tumor development in a variety of malignant tumors. CORT is widely expressed in the nervous, endocrine, and immune systems, with the best expression in inhibitory neurons in the cerebral cortex. CORT plays a critical role in a variety of physiological and disease processes, including immune responses, heart disease and neurological degeneration. Its overexpression significantly reduces the ability of glioma cells to proliferate and migrate in vitro and to form tumors in vivo. (PMID: 38292193)

References:

1, He Z, et al. Genes Dis. 2023;11(3):100977.                                                               
2. Zhao Y, et al. Theranostics. 2020;10(15):7015-7033.                                                  
3. Liang J,et al. Cardiovasc Diagn Ther. 2019;9(4):394-399.                                       
4. Gao Y, et al. Commun Biol. 2024;7(1):132.