Recombinant Human CSF1R/CD115 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3590

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Validation Data Gallery

• 

  Purity of Recombinant Human CSF1R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human CSF1R protein Ile20-Glu512 (Accession# P07333-1) with a rabbit IgG Fc tag at the C-terminus
• GeneID: 1436
• Accession: P07333-1
• PredictedSize: 80.8 kDa
• SDS-PAGE: 90-110 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CSF1R (colony-stimulating factor 1 receptor) belongs to the type III protein tyrosine kinase receptor family. CSF1R is ubiquitously expressed in macrophages, microglia, osteoclasts, and myeloid dendritic cells, but is rarely expressed in hematopoietic stem cells.CSF1R-mediated signaling is crucial for the differentiation and survival of the mononuclear phagocyte system and macrophages in particular.

References:

1.Cannarile MA, et al. (2017) J Immunother Cancer.18;5(1):53.
2.Wen J, et al. (2023)  Eur J Med Chem. 5;245(Pt 1):114884.