Recombinant Human FGL1 protein (rFc Tag)

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• Recombinant Human FGL1 protein (rFc Tag) (Eg2765)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2765

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Validation Data Gallery

• 

  Purity of Recombinant Human FGL1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human FGL1 protein Leu23-Ile312 (Accession# Q08830) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 2267
• Accession: Q08830
• PredictedSize: 60 kDa
• SDS-PAGE: 55-65 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in 20mM Tris, 300mM NaCl ,pH8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Fibrinogen-like 1 (FGL1), also termed hepatocyte-derived fibrinogen-related protein 1 (HFREP1) or hepassocin, is a predominantly liver expressed protein that has been implicated as both a hepatoprotectant and a hepatocyte mitogen. FGL1 expression is decreased in hepatocellular carcinoma (HCC), and it may play a role in the development of hepatocellular carcinomas.

References:

1. Hara, H et al. Biochimica et biophysica acta vol. 1520,1 (2001): 45-53.
2. Li, Chang-Yan et al. Gut vol. 59,6 (2010): 817-26.
3. Chen, Jiongming et al. Biomarker research vol. 12,1 53. 31 May. 2024.