Recombinant Human GLP1R protein (rFc Tag)

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• Recombinant Human GLP1R protein (rFc Tag) (Eg4678)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg4678

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Validation Data Gallery

• 

  Purity of Recombinant Human GLP1R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human GLP1R protein Arg24-Glu139 (Accession# P43220) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 2740
• Accession: P43220
• PredictedSize: 39.1 kDa
• SDS-PAGE: 45-60 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

GLP1R (glucagon-like peptide-1 receptor) is a G protein-coupled receptor belonging to the secretin receptor super-family, also known as class B. GLP1R is widely distributed in pancreatic islets, muscles, gastrointestinal tract, lung, liver, pancreas, and other tissues or organs. Moreover, GLP1R agonist has been reported to induce autophagy of endometrial carcinoma cells, and high GLP1R expression may be associated with good prognosis of endometrial carcinoma patients, suggesting that GLP1R is likely to participate in the progression of endometrial carcinoma.

References:

1. Ranka Kanda, et al. (2018) BMC Cancer. 18(1):657.
2. Julia Ast, et al. (2021) EBioMedicine. 74:103739.
3. Wu Li, et al. (2022) J Clin Lab Anal. 36(10):e24604.