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Recombinant Human IL-3RB/CD131 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1662

Validation Data Gallery

  • Purity of Recombinant Human IL-3RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-3RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human IL-3RB protein Trp17-Trp443 (Accession# P32927-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 1439
Accession P32927-1
PredictedSize 75.0 kDa
SDS-PAGE 75-100 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CSF2RB, also known as CD131, IL3RB, IL5RB, SMDP5, and CDw131, is a gene in humans that encodes the beta chain of the receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF), as well as IL-3 and IL-5. The protein is a transmembrane receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. In unstimulated conditions, CSF2RB interacts constitutively with JAK1, and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PMID: 1495999; 9516124).

References:

1. Tavernier J. et al. (1992). Proc Natl Acad Sci U S A. 89(15):7041-7045.
2. Ogata N. et al. (1998). Blood. 91(7):2264-2271.