Recombinant Human IL-22RA2 protein (rFc Tag)

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• Recombinant Human IL-22RA2 protein (rFc Tag) (Eg2825)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2825

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Validation Data Gallery

• 

  Purity of Recombinant Human IL-22RA2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human IL-22RA2 protein Thr22-Pro231 (Accession# Q969J5-2) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 116379
• Accession: Q969J5-2
• PredictedSize: 50.7 kDa
• SDS-PAGE: 62-80 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

The IL-22 binding protein (IL-22BP) is encoded by the IL22RA2 gene. IL-22BP has been shown to be expressed by distinct dendritic cell populations in mesenteric lymph nodes and the gut of rodents. It has also been recently shown that IL-22BP expressed by T cells plays an important role for IBD development in humans and IBD mouse models.

References:

1. Martin JC. et al. (2014). Mucosal Immunol. 7:101–113.
2. Huber S. et al. (2012). Nature. 491:259–263.
3. Pelczar P. et al. (2016). Science. 354:358–362.