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Recombinant Human KIR2DL4 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1895

Validation Data Gallery

  • Purity of Recombinant Human KIR2DL4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human KIR2DL4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human KIR2DL4 protein His24-His242 (Accession# Q99706-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 3805
Accession Q99706-1
PredictedSize 50.3 kDa
SDS-PAGE 52-68 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells that regulate their responsiveness to signals received from their environment. Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4, also known as CD158D and KIR103AS) is an unusual member of the KIRs family, which activates the cytotoxicity of NK cells. KIR2DL4 has two immunoglobulin domains and a single immunoreceptor tyrosine-based inhibition motif (ITIM) in the cytoplasmic tail with weak inhibitory potential.

References:

1. Sumati Rajagopalan, Eric O Long. (2012). Front Immunol. Aug 20:3:258.
2. Mathias Faure, Eric O Long. (2002). J Immunol. Jun 15;168(12):6208-14.
3. Sumati Rajagopalan, et al. (2006). PLoS Biol. Jan;4(1):e9.
4. Akiko Kikuchi-Maki, et al. (2003). J Immunol. Oct 1;171(7):3415-25.