Recombinant Human NKG2C/CD159c protein (rFc Tag)

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• Recombinant Human NKG2C/CD159c protein (rFc Tag) (Eg2639)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2639

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Validation Data Gallery

• 

  Purity of Recombinant Human NKG2C was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human NKG2C protein Ile94-Leu231 (Accession# P26717) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 3822
• Accession: P26717
• PredictedSize: 41.8 kDa
• SDS-PAGE: 45-60 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

NKG2C, also known as KLRC2 and CD159c, is an activating receptor of natural killer (NK) cells and plays a significant role in immune surveillance and host resistance against viruses and tumors (PMID: 36899273). It is an immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PMID: 30134159; 37264229; 9754572).

References:

1. Siemaszko J. et al. (2023). Arch Immunol Ther Exp (Warsz). 71(1):9.
2. Rölle A. et al. (2018). Cell Rep. 24(8):1967-1976.e4.
3. Lin Z. et al. (2023). Nat Immunol. 24(7):1087-1097.
4. Llano M. et al. (1998). Eur J Immunol. 28(9):2854-2863.