Recombinant Human ILT-3/LILRB4 protein (rFc Tag)

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• Recombinant Human ILT-3/LILRB4 protein (rFc Tag) (Eg1743)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1743

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Validation Data Gallery

• 

  Purity of Recombinant Human ILT-3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human ILT-3 protein Gln22-Glu259 (Accession# AAH26309.1) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 11006
• Accession: AAH26309.1
• PredictedSize: 52.3 kDa
• SDS-PAGE: 55-70 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

LILRB4 is an inhibitory receptor in the LILR family mainly expressed on normal and malignant human cells of myeloid origin. LILRB4 is activated and subsequently recruits adaptors to cytoplasmic immunoreceptor tyrosine inhibitory motifs to initiate different signaling cascades, thus playing an important role in physiological and pathological conditions, including autoimmune diseases, microbial infections, and cancers.

References:

1. Yang, Xing et al. Nature immunology vol. 26,9 (2025): 1567-1580.
2. Deng, Mi et al. Nature vol. 562,7728 (2018): 605-609.
3. Xie, Li et al. Cell death & disease vol. 15,7 515. 18 Jul. 2024