Recombinant Human PGLYRP1 protein (mFc Tag)

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• Recombinant Human PGLYRP1 protein (mFc Tag) (Eg3666)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

mFc Tag

Activity

not tested

Cat no : Eg3666

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Validation Data Gallery

• 

  Purity of Recombinant Human PGLYRP1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human PGLYRP1 protein Gln22-Pro196 (Accession# O75594) with a mouse IgG Fc tag at the C-terminus.
• GeneID: 8993
• Accession: O75594
• PredictedSize: 46.1 kDa
• SDS-PAGE: 44-53 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Peptidoglycan recognition protein 1 (PGLYRP1, also known as PGRP-S) belongs to a family of evolutionary conserved innate immunity proteins, which in mammals also include PGLYRP2, PGLYRP3, and PGLYRP4. PGLYRP1 is highly expressed in polymorphonuclear leukocytes and to a lesser extent in many non-immune cells. It recognizes bacterial peptidoglycan and functions in antibacterial immunity and inflammation. PGLYRP1 has been identified as a ligand for TREM-1.

References:

1. Guan R. et al. (2007). Trends Microbiol. 15(3):127-134.
2. Dziarski R. et al. (2010). Innate Immun. 16(3):168-174.
3. Read CB. et al. (2015). J Immunol. 194(4):1417-1421.