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Recombinant Human Mammaglobin A protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2887

Validation Data Gallery

  • Purity of Recombinant Human Mammaglobin A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Mammaglobin A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human Mammaglobin A protein Gly19-Phe93 (Accession# Q13296-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 4250
Accession Q13296-1
PredictedSize 34.5 kDa
SDS-PAGE 36-48 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

SCGB2A2 (secretoglobin family 2A member 2), also known as mammaglobin A, is a glycoprotein that belongs to a larger family called uteroglobin. SCGB2A2 is a breast cancer-associated antigen almost exclusively over-expressed in primary and metastatic human breast cancers, making it a specific molecular marker and a potential therapeutic target for BC. It is predicted to be involved in the androgen receptor signaling pathway and is believed to be located in the extracellular region, active in the extracellular space.

References:

1. Talaat, I. M. et al. (2020). Sci Rep.10(1):13061. 
2. Shi CX. et al. (2004). Mol Ther. 10(4), 758–767.
3. Zafrakas M. et al. (2006). BMC Cancer. 6:88.