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Recombinant Human Stanniocalcin 2 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3119

Validation Data Gallery

  • Purity of Recombinant Human Stanniocalcin 2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Stanniocalcin 2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human Stanniocalcin 2 protein Thr25-Arg302 (Accession# O76061) with a rabbit IgG Fc tag at the C-terminus.
GeneID 8614
Accession O76061
PredictedSize 56.7 kDa
SDS-PAGE 55-65 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

STC2 (Stanniocalcin 2) belongs to the highly conserved family of secreted glycoprotein hormones, which are glycoproteins. STC2 acts as a glycosylated disulfide-linked dimeric protein hormone that regulates calcium and phosphate secretion. STC2 is highly expressed in breast, muscle, cardiac, testicular and pancreatic tissues, and plays a role in a wide variety of biological processes, including calcium and phosphate regulation, cytoprotection, cell development and angiogenesis. STC2 expression appears significantly altered in a variety of tumor cells and tumor tissues, suggesting that it may be involved in tumorigenesis, development and prognosis. (PMID: 36764215)

References:

1.Jiang K, et al. Redox Biol. 2023;60:102626.                                                                
2. Qie S, Sang N. J Exp Clin Cancer Res. 2022;41(1):161.                                         
3. Jiang ZH, et al. Front Genet. 2022;13:927046.