Recombinant Human TGFBR3L protein (rFc Tag)

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• Recombinant Human TGFBR3L protein (rFc Tag) (Eg4201)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg4201

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Validation Data Gallery

• 

  Purity of Recombinant Human TGFBR3L was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human TGFBR3L protein Leu17-Pro244 (Accession# H3BV60-1) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 100507588
• Accession: H3BV60-1
• PredictedSize: 50.3 kDa
• SDS-PAGE: 60-70 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Transforming growth factor beta receptor 3 like (TGFBR3L) is a transmembrane protein selectively expressed in pituitary gonadotroph cells.TGFBR3L shows sequence similarity to transforming growth factor betareceptor 3 (TGFBR3), also called betaglycan, that has been detected in rodent pituitary gland and is suggested as an inhibin A co-receptor. TGFBR3L was shown to function as an inhibin B co-receptor in mice, as TGFBR3L knockout female mice presented a modest increase in FSH levels that was sufficient to enhance ovarian folliculogenesis and litter size.

References:

1.Cheung LYM.et al. (2018). Endocrinology 159.(12):3910-3924.
2.Fletcher PA.et al. (2019). Front Endocrinol (Lausanne).10:623.
3.Zhang S.et al. (2020). Nat Commun.11(1):5275.
4.Wang Y.et al. (2021). Sci Adv.7(51):eabl4391.
5.Bernard DJ.et al. (2020). Trends Endocrinol Metab.31(1):37-45.