Recombinant Human TNFSF18 protein (His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg32094
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human TNFSF18 protein Gln50-Ser177 (Accession# Q9UNG2) with a His tag at the N-terminus. |
| GeneID | 8995 |
| Accession | Q9UNG2 |
| PredictedSize | 20.9 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
TNFSF18 is also named as Glucocorticoid-induced TNF-related ligand (hGITRL). GITR is a gene coding for a member of the TNF receptor superfamily. GITR activation by its ligand (GITRL) influences the activity of effector and regulatory T cells, thus participating in the development of immune response against tumours and infectious agents, as well as in autoimmune and inflammatory diseases. GITR-GITRL interactions co-stimulate both responder T-cell functions and the suppressive functions of TReg cells. GITRL is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
References:
1. Nocentini, Giuseppe et al. European journal of immunology vol. 37,5 (2007): 1165-9. 2. Shevach, Ethan M, and Geoffrey L Stephens. Nature reviews. Immunology vol. 6,8 (2006): 613-8. 3. Lacal, Pedro Miguel et al. The Journal of pharmacology and experimental therapeutics vol. 347,1 (2013): 164-72.