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Recombinant Human DcR2 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3487

Validation Data Gallery

  • Purity of Recombinant Human DcR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human DcR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human DcR2 protein Ala56-His211 (Accession# Q9UBN6) with a rabbit IgG Fc tag at the C-terminus.
GeneID 8793
Accession Q9UBN6
PredictedSize 43.1 kDa
SDS-PAGE 45-70 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Decoy receptor 2 (DcR2) is one of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors and suppresses TRAIL-induced apoptosis. Its expression, like the other three TRAIL receptors (i.e., DR4, DR5, and DcR1), is regulated by p53. Previous studies found that DcR2 was highly expressed in senescent tumor cells and was associated with the degree of tumor differentiation . DcR2 is also expressed in activated senescent hepatic stellate cell, which protects senescent cell from cytotoxicity, eventually resulting in liver fibrosis .

References:

1.Chen, Jia et al. (2019) Biochemistry.44(5):1063-1074. 
2.Liu, Xiangguo et al. (2005) Biochemistry.65(20):9169-9175. 
3.Yao, Zhuotian et al. (2023) Biochemistry.113(1):e22004.