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Recombinant Human TREM2 protein (His Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Cat no : Eg0747

Validation Data Gallery

  • Purity of Recombinant Human TREM2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human TREM2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human TREM2 protein His19-Lys174 (Accession# AAH32362.1) with a His tag at the C-terminus.
GeneID 54209
Accession AAH32362.1
PredictedSize 18.5 kDa
SDS-PAGE 22-32 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia. TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles. It associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases.

References:

1. Guo, Tianshu. et al. (2022). Front Immunol. 13:963373.
2. Ferri, Evelyn. et al. (2021). Frontiers in molecular biosciences. 7:627931.
3. Diaz-Lucena, Daniela. et al. (2021). Acta Neuropathol. 141(6):841-859. 
4. Liu, Wenwu. et al. (2023). Clin Chim Acta. 548:117499.
5. Piccio, Laura. et al. (2016). Acta Neuropathol. 131(6):925-33.
6. Hu, Nan. et al. (2014). J Alzheimers Dis. 38(3):497-501.