Recombinant Human Prealbumin/Transthyretin protein (His Tag)

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• Recombinant Human Prealbumin/Transthyretin protein (His Tag) (Eg0930)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Cat no : Eg0930

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Validation Data Gallery

• 

  Purity of Recombinant Human Prealbumin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Human Prealbumin protein Gly21-Glu147 (Accession# P02766) with a His tag at the N-terminus.
• GeneID: 7276
• Accession: P02766
• PredictedSize: 14.8 kDa
• SDS-PAGE: 16 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors.

References:

1.Iwasaki, T. et al. (2011) Neuropathology. 31(6):632-8.
2.Sousa, JC. et al. (2006) Neurobiol Aging. 28(5):713-8.
3.Mizuguchi, M. et al. (2024) Struct Fold Des. 32(12):2181-2182.
4.Angueira, A. et al. (2024) JAMA CARDIOL. 2024-12-04