ICOSLG Monoclonal antibody

ICOSLG Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG2a









Cat no : 67003-1-Ig


B7 H2, B7 homolog 2, B7 like protein Gl50, B7 related protein 1, B7H2, B7RP 1, B7RP1, CD275, GL50, ICOS L, ICOS ligand, ICOSL, ICOSLG, KIAA0653, LICOS

Tested Applications

Positive WB detected inHL-60 cells, Daudi cells, HUVEC cells, JAR cells

Recommended dilution

Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

67003-1-Ig targets ICOSLG in WB, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen ICOSLG fusion protein Ag6799
Full Name inducible T-cell co-stimulator ligand
Calculated Molecular Weight 33 kDa, 34 kDa
Observed Molecular Weight 60-65 kDa, 28-35 kDa
GenBank Accession NumberBC064637
Gene Symbol ICOSLG
Gene ID (NCBI) 23308
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ICOSLG, also known as B7H2 or GL50, is a type I transmembrane glycoprotein belonging to the B7 ligand family. ICOSLG is extensively expressed on professional antigen-presenting cells including B cells, macrophages, and dendritic cells, as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells (PMID: 33756276; 35800767). It is a specific ligand for the T-cell-specific cell surface receptor ICOS and acts as a co-stimulatory molecule (PMID: 11023515; 11007762). The interaction of ICOSLG and ICOS plays important roles in the activation, proliferation, differentiation, and cytokine production of T cells as well as in the antibody secretion from B cells during secondary immune responses (PMID: 21851236).


Product Specific Protocols
WB protocol for ICOSLG antibody 67003-1-IgDownload protocol
Standard Protocols
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