By Product Type
By Research Area
Images See all
Recombinant human IFN-gamma (Cat.NO. HZ-1301) inhibits the growth of HT-29 cell line (human colorectal adenocarcinoma cell line) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human IFN-gamma (5 ng/mL HZ-1301) is neutralized by mouse anti-human IFN-gamma monoclonal antibody 69007-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 100-400 ng/mL.
Interferon gamma (IFNG) is a soluble cytokine that is the only member of the type II class of interferons. It is secreted by Th1 cells, cytotoxic T cells and NK cells. The cytokine is associated with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. It plays crucial roles in pathogen clearance. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. It has been identified in many studies as a biomarker for pleural tuberculosis (TB). Mutations in this gene are associated with aplastic anemia.
This antibody is used to Block/Neutralize Interferon gamma protein.