CoraLite®647-conjugated IL-6 Monoclonal antibody
IL-6 Monoclonal Antibody for FC (Intra)
Host / Isotype
Mouse / IgG1
CoraLite®647 Fluorescent Dye
Cat no : CL647-69001
|Positive FC detected in||LPS and Brefeldin A treated HUVEC cells, HUVEC cells|
|Sample-dependent, check data in validation data gallery|
CL647-69001 targets IL-6 in FC (Intra) applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||IL-6 fusion protein HZ-1019|
|Full Name||interleukin 6 (interferon, beta 2)|
|Gene ID (NCBI)||3569|
|Conjugate||CoraLite®647 Fluorescent Dye|
|Excitation/Emission maxima wavelengths||650 nm / 665 nm|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.|
|Storage Conditions||Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.|
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
This antibody is used to Block/Neutralize IL6 protein.