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IL-12B Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 17645-1-AP

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Con: 20 μg/150 μl

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Tested Applications

Applications:
WB, ELISA
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IL-12B Antibody WB Recombinant protein protein 17645-1-AP

Recombinant protein were subjected to SDS PAGE followed by western blot with 17645-1-AP( IL-12B antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours

Species specificity:
human
Positive WB detected in:
Recombinant protein, Recombinant protein protein
Recommended dilution:
WB : 1:500-1:2000
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
IL-12B fusion protein Ag11837
Full name:
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Calculated molecular weight:
328aa,37 kDa
Observed molecular weight:
39 kDa
GenBank accession number:
BC067498
Gene ID (NCBI):
3593
Gene symbol
IL12B
Synonyms
CLMF, CLMF p40, CLMF2, IL 12 subunit p40, IL 12B, IL12B, Interleukin 12 subunit beta, NKSF, NKSF2

Background

Interleukin-12 (IL-12), is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.


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