IL-17RA Recombinant antibody

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  WB analysis using 84535-2-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 84535-2-RR (IL17RA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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  Affinity and Kinetic Characterization of 84535-2-RR

  Biolayer interferometry (BLl) kinetic assays of 84535-2-RR against Human IL17RA were performed. The affinity constant is below 1 pM.

IL-17RA Uni-rAb^TM Recombinant Antibody for WB, ELISA

Cat No. 84535-2-RR

Clone No.241891E11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

CD217, IL17RA, 241891E11, CANDF5, CDw217

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Tested Applications

• Positive WB detected in: THP-1 cells, Jurkat cells, K-562 cells, MOLT-4 cells, U-937 cells, Raji cells, U2OS cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

84535-2-RR targets IL-17RA in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: IL-17RA fusion protein Eg2317
• Full Name: interleukin 17 receptor A
• Calculated Molecular Weight: 866 aa, 96 kDa
• Observed Molecular Weight: 100-130 kDa
• GenBank Accession Number: BC011624
• Gene Symbol: IL17RA
• Gene ID (NCBI): 23765
• RRID: AB_3672042
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q96F46
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Interleukin-17 receptor A (IL17A) is a major effector cytokine of the innate and adaptive immune system and is involved in antimicrobial host defense and maintenance of tissue integrity. It has been shown that IL-17A is involved in the pathogenesis of asthma and allergy and regulates local immune and inflammatory processes in bone tissue and is involved in the onset and progression of osteoporosis. In addition to this, due to polymorphisms in the IL17RA gene, it leads to the development of Fanconi anemia.