Product Information
33459-1-PBS targets IQCG in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37506 Product name: Recombinant human IQCG protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-372 aa of BC004816 Sequence: TDQLSILNYIMPVQYEGRQSICVKSREMNLEGTNLDKLPMDSTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSHVIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQIAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDKVDSKDSKGKGKGKDKRRGKKK Predict reactive species |
| Full Name | IQ motif containing G |
| Calculated Molecular Weight | 51 kDa |
| Observed Molecular Weight | 50 kDa |
| GenBank Accession Number | BC004816 |
| Gene Symbol | IQCG |
| Gene ID (NCBI) | 84223 |
| RRID | AB_3742980 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9H095 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Human IQ motif containing G (IQCG) gene was first reported to be involved in the chromosome translocation in a case of acute T-lymphoid/myeloid leukemia. The expression of Iqcg is prominently enriched in the testis of mice and reveals an ordered expression pattern during spermatogenesis. Iqcg knockout (KO) mice are sterile, due to the severe malformation and total immobility of their spermatozoa. The axoneme in the KO sperm flagellum is disorganized and hardly any typical normal "9+2" pattern, composed of two central microtubules surrounded by nine microtubular doublets, could be found in the KO spermatids. However, the cilia structures in the trachea and oviduct, as well as histological appearances of other major tissues, remain unaffected in the KO mice, suggesting Iqcg's specific role in spermiogenesis (PMID: 24849454).
