ISLR2 Polyclonal antibody, PBS Only

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• ISLR2 Polyclonal antibody, PBS Only (24814-1-PBS)

• 

  WB analysis using 24814-1-AP (same clone as 24814-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24814-1-AP (ISLR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24814-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 24814-1-AP (same clone as 24814-1-PBS)

  WB result of ISLR2 antibody (24814-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-ISLR2 transfected SH-SY5Y cells. This data was developed using the same antibody clone with 24814-1-PBS in a different storage buffer formulation.

ISLR2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 24814-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, Indirect ELISA

Synonyms

Immunoglobulin superfamily containing leucine-rich repeat protein 2, KIAA1465, Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein, LINX

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Product Information

24814-1-PBS targets ISLR2 in WB, Indirect ELISA applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag20518

  Product name: Recombinant human ISLR2 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 396-745 aa of BC152429

  Sequence: ERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFLLVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPAGGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYSDRLPLGAEAVNIAQEINGNYRQTAG

• Full Name: immunoglobulin superfamily containing leucine-rich repeat 2
• Calculated Molecular Weight: 745 aa, 79 kDa
• Observed Molecular Weight: 79 kDa, 130 kDa
• GenBank Accession Number: BC152429
• Gene Symbol: ISLR2
• Gene ID (NCBI): 57611
• RRID: AB_3669451
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q6UXK2
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2), also known as LINX. It is expected to be located in cell membrane and the protein is mainly expressed in brain and testis. While the first knockout mouse had impaired development of the internal capsule and no hydrocephalus, a much more recent independent knockout mouse was shown to additionally have severe hydrocephalus. Although the mechanism remains unclear, it may be related to the role of ISLR2 in reorganizing the cytoskeleton of developing neurons (PMID: 30483960). The calculated molecular weight of ISLR2 is 79 kDa, this target has phosphorylation modification and glycosylation modification. And the 130 kDa band is glycosylated (PMID: 29739947).