ITPR3 Polyclonal antibody, PBS Only

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• ITPR3 Polyclonal antibody, PBS Only (20729-1-PBS)

• 

  WB analysis using 20729-1-AP (same clone as 20729-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20729-1-AP (ITPR3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse small intestine using 20729-1-AP (same clone as 20729-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse colon using 20729-1-AP (same clone as 20729-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse cerebellum using 20729-1-AP (same clone as 20729-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20729-1-PBS in a different storage buffer formulation.

ITPR3 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 20729-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Synonyms

InsP3R3, IP3R, IP3R 3, IP3R3

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Product Information

20729-1-PBS targets ITPR3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: inositol 1,4,5-triphosphate receptor, type 3
• Calculated Molecular Weight: 304 kDa
• Observed Molecular Weight: 250-300 kDa
• GenBank Accession Number: NM_002224
• Gene Symbol: ITPR3
• Gene ID (NCBI): 3710
• RRID: AB_3669343
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q14573
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ITPRs family have three members: ITPR1, ITPR2 and ITPR3. For ITPR3, it is associated with cervical squamous cell carcinoma, glioblastoma, cholangiocarcinoma and other cancers. Inositol 1,4, 5-triphosphate receptor type 3 (ITPR3) was found to be apical-located in bile duct cells, and disruption of lipid raft in the segregated bile duct unit (IBDU) redistributes ITPR3 and impairs Ca2+ waves. (PMID: 35580861, PMID:35852334)