Product Information
86917-1-PBS targets KAT2B/PCAF in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Ag30238 Product name: Recombinant human KAT2B protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 366-424 aa of BC060823 Sequence: DQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEAN Predict reactive species |
| Full Name | K(lysine) acetyltransferase 2B |
| Calculated Molecular Weight | 93 kDa |
| Observed Molecular Weight | 93 kDa |
| GenBank Accession Number | BC060823 |
| Gene Symbol | PCAF/KAT2B |
| Gene ID (NCBI) | 8850 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q92831 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
KAT2B, also known as PCAF (p300/CBP-associated factor), is a crucial transcriptional coactivator that possesses intrinsic histone acetyltransferase (HAT) activity. It primarily acetylates histone H3 at lysine 9 (H3K9ac) and lysine 14 (H3K14ac), a modification associated with open chromatin and active gene transcription. Functionally, PCAF is recruited to promoters by interacting with various transcription factors (such as p53, NF-κB, and nuclear receptors) and larger complexes like the p300/CBP cointegrator complex. It plays pivotal roles in diverse cellular processes, including cell cycle progression, differentiation, metabolism, DNA damage response, and tumor suppression or promotion in a context-dependent manner. Due to its involvement in critical pathways, PCAF is a significant protein of interest in epigenetics, cancer biology, and neurodevelopmental research.
