KATNAL1 Recombinant antibody

• 

  WB analysis using 85382-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85382-1-RR (KATNAL1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 85382-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85382-1-RR (KATNAL1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

KATNAL1 Uni-rAb^TM Recombinant Antibody for WB, ELISA

Cat No. 85382-1-RR

Clone No.242796B5

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, ELISA

Synonyms

p60 katanin like 1, Katanin p60 subunit A-like 1, katanin p60 subunit A like 1, Katanin p60 ATPase-containing subunit A-like 1, EC:5.6.1.1

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Tested Applications

• Positive WB detected in: HeLa cells, MCF-7 cells, HEK-293 cells, Jurkat cells, PC-12 cells

Recommended dilution

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

85382-1-RR targets KATNAL1 in WB, ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: KATNAL1 fusion protein Ag13960
• Full Name: katanin p60 subunit A-like 1
• Calculated Molecular Weight: 490 aa, 55 kDa
• Observed Molecular Weight: 50-55 kDa
• GenBank Accession Number: BC000612
• Gene Symbol: KATNAL1
• Gene ID (NCBI): 84056
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9BW62
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

KATNAL1 belongs to a family of microtubule-severing proteins and contains an N-terminal microtubule interaction and trafficking (MIT) domain, an ATPase AAA-type core domain, and a C-terminal Vps4_C domain. KATNAL1 is involved in regulating microtubule dynamics, which is essential for spermiogenesis and male fertility. It severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays(PMID: 22654668). In neurons, KATNAL1 plays a role in microtubule rearrangement during neuronal migration and process elongation. Additionally, mutations in KATNAL1 have been associated with intellectual disability and microcephaly in humans(PMID: 30448058).