Product Information
18067-1-PBS targets KCNA1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag12699 Product name: Recombinant human KCNA1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-163 aa of BC101733 Sequence: MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESS Predict reactive species |
| Full Name | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) |
| Calculated Molecular Weight | 495 aa, 56 kDa |
| Observed Molecular Weight | 86 kDa |
| GenBank Accession Number | BC101733 |
| Gene Symbol | KCNA1 |
| Gene ID (NCBI) | 3736 |
| RRID | AB_3741943 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q09470 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Potassium voltage-gated channel subfamily A member 1 (KCNA1, also known as Kv1.1) is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PMID: 19903818; 8845167). KCNA1 expression was reduced in human cancers, and this decrease correlated with an increase in breast cancer aggressiveness (PMID: 23774215). Furthermore, Kv1.1 is expressed in the brain as a mature glycoprotein, which is reported to be 86 kDa (PMID: 16305740).
