Kv1.4-Specific Polyclonal antibody

Kv1.4-Specific Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

3

Cat no : 19697-1-AP

Synonyms

HBK4, HK1, HPCN2, HUKII, KCNA4, KCNA4L, KCNA8, Kv1.4, PCN2

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Validation Data Gallery

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  WB analysis of mouse liver using 19697-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 19697-1-AP (Kv1.4-Specific antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse liver tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 3 publications below

Product Information

19697-1-AP targets Kv1.4-Specific in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: potassium voltage-gated channel, shaker-related subfamily, member 4
• Calculated Molecular Weight: 73 kDa
• Observed Molecular Weight: 73 kDa
• GenBank Accession Number: NM_002233
• Gene Symbol: KCNA4
• Gene ID (NCBI): 3739
• RRID: AB_10638919
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

KCNA4, also named as KCNA4L, HBK4, HUKII, HK1 and HPCN2, belongs to the potassium channel family and A (Shaker) subfamily. KCN4 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The antibody is specific to KCN4.

Publications

Species	Application	Title
rat	WB	Cell Physiol Biochem; MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction.; Authors - Xue Liu
rat	WB	J Cell Sci; Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity.; Authors - Xueting Gao
rat	WB	J Cell Mol Med; Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.; Authors - Yi Guan