Product Information
30853-1-PBS targets KCNH2 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag34230 Product name: Recombinant human KCNH2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 880-1159 aa of NM_000238 Sequence: GFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS Predict reactive species |
| Full Name | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
| Calculated Molecular Weight | 127 kDa |
| Observed Molecular Weight | 100-120 kDa |
| GenBank Accession Number | NM_000238 |
| Gene Symbol | KCNH2 |
| Gene ID (NCBI) | 3757 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q12809 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Voltage-gated inwardly rectifying potassium channel KCNH2 (also known as ERG1, Kv11.1, and HERG) is a key member of the voltage-gated potassium (Kv) channel family (PMID: 16382104). Growing evidence has indicated that the association between KCNH2 and hypoglycemia, an adverse effect induced by KCNH2 blockers, implies a potential regulatory role of this channel in the maintenance of blood glucose homeostasis (PMID: 21224236; 31863282). Mutations in the KCNH2 gene are recognized as one of the etiological factors of congenital long QT syndrome (LQTS), a rare syndrome that carries an increased risk of cardiac arrhythmias, including the polymorphic ventricular tachycardia termed torsades de pointes (TdP) (PMID: 17143043; 16554806).
