KCNQ5 Polyclonal antibody, PBS Only

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• KCNQ5 Polyclonal antibody, PBS Only (28000-1-PBS)

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  WB analysis using 28000-1-AP (same clone as 28000-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28000-1-AP (KCNQ5 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28000-1-PBS in a different storage buffer formulation.

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  IP experiment of Raji using 28000-1-AP (same clone as 28000-1-PBS)

  IP result of anti-KCNQ5 (IP:28000-1-AP, 4ug; Detection:28000-1-AP 1:500) with Raji cells lysate 1600 ug. This data was developed using the same antibody clone with 28000-1-PBS in a different storage buffer formulation.

KCNQ5 Polyclonal Antibody for WB, IP, Indirect ELISA

Cat No. 28000-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Synonyms

Voltage-gated potassium channel subunit Kv7.5, Potassium voltage-gated channel subfamily KQT member 5, Kv7.5, KQT-like 5, KQT like 5

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Product Information

28000-1-PBS targets KCNQ5 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag27622

  Product name: Recombinant human KCNQ5 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 785-932 aa of NM_001160130

  Sequence: MVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLK

• Full Name: potassium voltage-gated channel, KQT-like subfamily, member 5
• Calculated Molecular Weight: 102 kDa
• Observed Molecular Weight: 100 kDa
• GenBank Accession Number: NM_001160130
• Gene Symbol: KCNQ5
• Gene ID (NCBI): 56479
• RRID: AB_3742270
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9NR82
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Potassium voltage-gated channel subfamily Q member 5 (KCNQ5, also known as Kv7.5 and MRD46) is widely expressed in the brain and generates M-type current. It has a role in the regulation of neuronal excitability (PMID: 10816588). KCNQ5 mutations are associated with increased excitability and decreased repolarization reserve, lead to pathophysiology (PMID: 28669405).