Product Information
32898-1-PBS targets KCTD4 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37112 Product name: Recombinant human KCTD4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-259 aa of BC018063 Sequence: MERKINRREKEKEYEGKHNSLEDTDQGKNCKSTLMTLNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDADGHYFIDRDGLLFRHVLNFLRNGELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPRETTFLEITDNHDRSQGLRIFCNAPDFISKIKSRIVLVSKSRLDGFPEEFSISSNIIRFKYFIKSENGTRLVLKEDNTFVCTLETLKFEAIMMALKCGFRLLTSLDCSKGSIVHSDALHFIK Predict reactive species |
| Full Name | potassium channel tetramerisation domain containing 4 |
| Calculated Molecular Weight | 30 kDa |
| Observed Molecular Weight | 30 kDa |
| GenBank Accession Number | BC018063 |
| Gene Symbol | KCTD4 |
| Gene ID (NCBI) | 386618 |
| RRID | AB_3742780 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q8WVF5 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
The family of potassium channel tetramerization domain (KCTD) proteins consists of 26 members (PMID: 24268103). Potassium channel tetramerization domain containing 4 (KCTD4) is a protein that interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer. KCTD4 expression is upregulated in metastatic esophageal squamous cell carcinoma (ESCC), and high KCTD4 expression is associated with poor prognosis in patients with ESCC. This process activates fibroblasts in a paracrine manner, promoting cancer cell invasion via MMP24 signaling as positive feedback (PMID: 37799381).
