KDM5C Polyclonal antibody
KDM5C Polyclonal Antibody for IF, WB, ELISA
Host / Isotype
Rabbit / IgG
human, mouse, rat
WB, IF, ELISA
Cat no : 14426-1-AP
|Positive WB detected in||HeLa cells, Jurkat cells, MCF-7 cells|
|Positive IF detected in||HeLa cells|
|Western Blot (WB)||WB : 1:1000-1:5000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
14426-1-AP targets KDM5C in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KDM5C fusion protein Ag5791|
|Full Name||lysine (K)-specific demethylase 5C|
|Calculated molecular weight||176 kDa|
|Observed molecular weight||171-180 kDa|
|GenBank accession number||BC054499|
|Gene ID (NCBI)||8242|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
KDM5C belongs to the ARID protein family that harbors conserved DNA-binding motifs and acts as a histone H3 lysine 4 demethylase, suggesting a potential role in epigenetic regulation during development, cell differentiation (PMID:21575681). KDM5C protein is homologous to three other proteins of the human JARID1 family (JARID1A, JARID1B and JARID1C). This family shares several evolutionarily conserved domains, including the catalytic JmjC domain, JmjN domain, Arid/Bright domain, C5HC2 zinc-finger domain and two plant homeodomains (PHD), a motif that binds methyl-lysine residues (PMID:17320160,17320161).
|Product Specific Protocols|
|WB protocol for KDM5C antibody 14426-1-AP||Download protocol|
|IF protocol for KDM5C antibody 14426-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Int J Biol Sci
KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.
Novel Variations in the KDM5C Gene Causing X-Linked Intellectual Disability.
Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.