KDM5C Polyclonal antibody

KDM5C Polyclonal Antibody for IF, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 14426-1-AP


DXS1272E, Histone demethylase JARID1C, JARID1C, KDM5C, lysine (K) demethylase 5C, Lysine specific demethylase 5C, MRXJ, MRXSJ, Protein SmcX, Protein Xe169, SMCX, XE169

Tested Applications

Positive WB detected inHeLa cells, Jurkat cells, MCF-7 cells
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:5000
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

14426-1-AP targets KDM5C in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen KDM5C fusion protein Ag5791
Full Name lysine (K)-specific demethylase 5C
Calculated molecular weight 176 kDa
Observed molecular weight 171-180 kDa
GenBank accession numberBC054499
Gene symbol KDM5C
Gene ID (NCBI) 8242
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

KDM5C belongs to the ARID protein family that harbors conserved DNA-binding motifs and acts as a histone H3 lysine 4 demethylase, suggesting a potential role in epigenetic regulation during development, cell differentiation (PMID:21575681). KDM5C protein is homologous to three other proteins of the human JARID1 family (JARID1A, JARID1B and JARID1C). This family shares several evolutionarily conserved domains, including the catalytic JmjC domain, JmjN domain, Arid/Bright domain, C5HC2 zinc-finger domain and two plant homeodomains (PHD), a motif that binds methyl-lysine residues (PMID:17320160,17320161).


Product Specific Protocols
WB protocol for KDM5C antibody 14426-1-APDownload protocol
IF protocol for KDM5C antibody 14426-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Int J Biol Sci

KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.

Authors - Wenxia Xu

Neurol Genet

Novel Variations in the KDM5C Gene Causing X-Linked Intellectual Disability.

Authors - Po-Ming Wu


Inhibition of H3K27me3 Demethylases Promotes Plasmablast Formation.

Authors - Anna K Kania

Nat Metab

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.

Authors - Shi-Ting Li