Product Information
67537-1-PBS targets KLRB1/CD161 in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag27117 Product name: Recombinant human KLRB1,CD161 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 68-225 aa of BC114516 Sequence: KSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDS Predict reactive species |
| Full Name | killer cell lectin-like receptor subfamily B, member 1 |
| Calculated Molecular Weight | 225 aa, 25 kDa |
| Observed Molecular Weight | 32 kDa |
| GenBank Accession Number | BC114516 |
| Gene Symbol | CD161 |
| Gene ID (NCBI) | 3820 |
| ENSEMBL Gene ID | ENSG00000111796 |
| RRID | AB_2882756 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q12918 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).
