Tested Applications
| Positive WB detected in | A431 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
19698-1-AP targets LAMC2 in WB, IHC, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | laminin, gamma 2 |
| Calculated Molecular Weight | 131 kDa |
| Observed Molecular Weight | 140 kDa |
| GenBank Accession Number | NM_005562 |
| Gene Symbol | LAMC2 |
| Gene ID (NCBI) | 3918 |
| RRID | AB_10644139 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q13753 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
LAMC2, also named as LAMB2T and LAMNB2, is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. LAMC2 binds to cells via a high affinity receptor. Laminin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for LAMC2 antibody 19698-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The LAMC2 Polyclonal antibody (Cat# 19698-1-AP) has 19 citations. These appear in journals including Cancer Research, Science Translational Medicine, Journal for ImmunoTherapy of Cancer, Journal of Translational Medicine, International Journal of Molecular Medicine, Phytotherapy Research, Communications Biology, International Journal of Molecular Sciences, Molecular Medicine Reports, Scientific Reports, iScience, International Journal of Chronic Obstructive Pulmonary Disease, Toxicology and Applied Pharmacology, Phytochemistry, Journal of Proteomics, Neoplasma, Translational Cancer Research, and Cell Death & Disease. Research fields span cancer biology (bladder, breast, prostate, ovarian, gastric, lung, pancreatic, colorectal, esophageal, glioma), EMT, fibrosis, COPD, and extracellular matrix remodeling.
| Species | Application | Title |
|---|---|---|
Cancer Res A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer | ||
Sci Transl Med Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation | ||
J Immunother Cancer Gasdermin D antagonizes immunosuppression in prostate cancer by inducing LAMC2 degradation to block M2 macrophage polarization. | ||
J Transl Med Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction | ||
Int J Mol Med The Notch pathway mediates the angiotensin II-induced synthesis of extracellular matrix components in podocytes. | ||
Phytother Res Dioscin Suppresses Ovarian and Gastric Tumor Progression by Inhibiting ALDH1A3-Mediated Retinoic Acid Metabolism and Cancer Stemness. |
Reviews
What customers say
The single review for this product is highly positive, with a 5-star rating. The reviewer used the antibody for Western Blot on ARPE-19 cells at a 1:1000 dilution and reported obtaining a clear band, indicating strong specificity and reliable performance under these conditions.
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
Guorong (Verified Customer) (11-22-2022) | Clear band
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