|Positive WB detected in||HepG2 cells, human brain tissue|
|Positive IF detected in||HepG2 cells, HeLa cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
55273-1-AP targets LAMP1 in WB, IF,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, turtle|
|Host / Isotype||Rabbit / IgG|
|Full Name||lysosomal-associated membrane protein 1|
|Calculated molecular weight||45 kDa|
|Observed molecular weight||110 kDa|
|GenBank accession number||NM_005561|
|Gene ID (NCBI)||3916|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Aliquoting is unnecessary for -20oC storage.|
LAMP1 (also known as CD107a) is a 90-120 kDa heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis.
Reprod Biol Endocrinol
LIPOPHAGY: a novel form of steroidogenic activity within the LEYDIG cell during the reproductive cycle of turtle.
In Vivo Autophagy Up-Regulation of Small Intestine Enterocytes in Chinese Soft-Shelled Turtles during Hibernation.
Cell Death Dis
TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.
N-glycosylation of the AMPA-type glutamate receptor regulates cell surface expression and tetramer formation affecting channel function.
Aging (Albany NY)
in vivo cellular evidence of autophagic associated spermiophagy within the principal cells during sperm storage in epididymis of the turtle.
Cell Death Dis
The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Chun (Verified Customer) (12-05-2019)
a very good antibody
Cheryl (Verified Customer) (07-01-2019)
Robust antibody that works well for both IF and for Western blotting. Detects typical endosomal type structures by IF with little background and also picks up the multiple glycosylated forms of LAMP1 by Western blotting. Great value for money compared to alternatives from other suppliers.