LENG8 Polyclonal antibody, PBS Only

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• LENG8 Polyclonal antibody, PBS Only (13336-1-PBS)

• 

  WB analysis of A2780 using 13336-1-AP (same clone as 13336-1-PBS)

  A2780 cells were subjected to SDS PAGE followed by western blot with 13336-1-AP (LENG8 antibody) at dilution of 1:1200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13336-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 13336-1-AP (same clone as 13336-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 13336-1-AP (LENG8 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13336-1-PBS in a different storage buffer formulation.

• 

  FC experiment of HEK-293 using 13336-1-AP (same clone as 13336-1-PBS)

  1x10^6 HEK-293 cells were intracellularly stained with 0.25 ug LENG8 Polyclonal antibody (13336-1-AP) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Isotype Control (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). This data was developed using the same antibody clone with 13336-1-PBS in a different storage buffer formulation.

LENG8 Polyclonal Antibody for WB, FC (Intra), Indirect ELISA

Cat No. 13336-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, FC (Intra), Indirect ELISA

Synonyms

KIAA1932, pp13842

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Product Information

13336-1-PBS targets LENG8 in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag4153

  Product name: Recombinant human LENG8 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 501-800 aa of BC028048

  Sequence: EDPERELKKQKRAARFQHGHSRRLRLEPLVLQMSSLESSGADPDWQELQIVGTCPDITKHYLRLTCAPDPSTVRPVAVLKKSLCMVKCHWKEKQDYAFACEQMKSIRQDLTVQGIRTEFTVEVYETHARIALEKGDHEEFNQCQTQLKSLYAENLPGNVGEFTAYRILYYIFTKNSGDITTELAYLTRELKADPCVAHALALRTAWALGNYHRFFRLYCHAPCMSGYLVDKFADRERKVALKAMIKTFRPALPVSYLQAELAFEGEAACRAFLEPLGLAYTGPDNSSIDCRLSLAQLSAF

• Full Name: leukocyte receptor cluster (LRC) member 8
• Calculated Molecular Weight: 800 aa, 88 kDa
• Observed Molecular Weight: 86-88 kDa
• GenBank Accession Number: BC028048
• Gene Symbol: LENG8
• Gene ID (NCBI): 114823
• RRID: AB_1167573
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q96PV6
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

LENG8 is the core factor of the key RNA quality control system discovered in recent years, which plays a goalkeeper role in the regulation of eukaryotic gene expression. LENG8 promotes the recruitment of PAXT complex and RNA exonuclease, and mediates the degradation of abnormal RNA. It is a multifunctional evolutionarily conserved protein, which plays a key role from yeast to human beings. It is an important node molecule connecting gene post-transcriptional processing, RNA quality control and cell energy metabolism.