LPPR5 Polyclonal antibody, PBS Only

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• LPPR5 Polyclonal antibody, PBS Only (18842-1-PBS)

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  IHC staining of mouse brain using 18842-1-AP (same clone as 18842-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18842-1-AP (LPPR5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18842-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 18842-1-AP (same clone as 18842-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18842-1-AP (LPPR5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18842-1-PBS in a different storage buffer formulation.

LPPR5 Polyclonal Antibody for IHC, Indirect ELISA

Cat No. 18842-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, Indirect ELISA

Synonyms

PAP2D, Lipid phosphate phosphatase-related protein type 5, PAP2, Phosphatidic acid phosphatase type 2d, Phospholipid phosphatase-related protein type 5

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Product Information

18842-1-PBS targets LPPR5 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: phosphatidic acid phosphatase type 2
• Calculated Molecular Weight: 35 kDa
• GenBank Accession Number: NM_001010861
• Gene Symbol: PAP2D
• Gene ID (NCBI): 163404
• RRID: AB_3741956
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q32ZL2
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The lipid phosphate phosphatase-related proteins (LPPRs), also known as plasticity-related genes (PRGs), are a family of six transmembrane proteins that are enriched in brain. To date, five members have been identified (LPPR1-LPPR5). LPPR5 is an integral membrane protein linked to neuronal plasticity, which impedes NogoA- and LPA-mediated RhoA kinase signaling. LPPR5 modulates the Rho-GTPase pathway involved in cancer growth, vascularization, and the adaptive response to changes in the microenvironment. LPPR5 is pivotal in influencing growth, angiogenesis, and therapeutic resistance. (PMID: 26183180, PMID: 35328529)