LSR Polyclonal antibody, PBS Only

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• LSR Polyclonal antibody, PBS Only (18216-1-PBS)

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  WB analysis of HT-29 using 18216-1-AP (same clone as 18216-1-PBS)

  HT-29 cells (LSR+) and HeLa cells (LSR-) were subjected to SDS PAGE followed by western blot with 18216-1-AP (LSR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  WB analysis of HT-29 using 18216-1-AP (same clone as 18216-1-PBS)

  WB result of LSR antibody (18216-1-AP; 1:60000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LSR transfected HT-29 cells. This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  WB analysis using 18216-1-AP (same clone as 18216-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18216-1-AP (LSR antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse stomach using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse stomach tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse stomach using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse stomach tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse liver using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

LSR Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 18216-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

ILDR3, Lipolysis-stimulated lipoprotein receptor, LISCH, LISCH7

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Product Information

18216-1-PBS targets LSR in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag12961

  Product name: Recombinant human LSR protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 339-589 aa of BC004381

  Sequence: SMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV

• Full Name: lipolysis stimulated lipoprotein receptor
• Calculated Molecular Weight: 71 kDa
• Observed Molecular Weight: 60-70 kDa, 56 kDa
• GenBank Accession Number: BC004381
• Gene Symbol: LSR
• Gene ID (NCBI): 51599
• RRID: AB_2250137
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q86X29
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

LSR (lipolysis stimulated lipoprotein receptor) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids (PMID: 10224102). This remnant receptor binds both apoB- and apoE-containing lipoproteins and displays greatest affinity for TG-rich lipoproteins. Distribution of LSR causes embryonic lethality in mice, indicating that the expression of LSR is critical for liver and embryonic development (PMID: 15265030). Investigations show that LSR is a multimer consisting of α subunit (68 kDa) and β subunit (56 kDa) associated through disulfide bridges (PMID: 10224102; 19188430; 18644789).