Home
Products
Primary Antibodies
Flow Cytometry Antibodies
Anti-Human LTBR Rabbit Recombinant Antibody, PBS Only (98626-2-PBS)

Anti-Human LTBR Rabbit Recombinant Antibody, PBS Only

Name: Anti-Human LTBR Rabbit Recombinant Antibody, PBS Only, 1mg
Brand: Proteintech
SKU: 98626-2-PBS-1MG

LTBR Uni-rAb^® Recombinant Antibody for FC

Cat No. 98626-2-PBS

Clone No.251739F2

Review Product

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

D12S370, LT BETA R, Lymphotoxin beta receptor, Lymphotoxin-beta receptor, TNF R III

Formulation: PBS Only

PBS, Azide

PBS Only

Conjugate: Unconjugated

Size/Concentration:

SKU:

-/ -

Freight/Packing: -

Quantity

- +

Request bulk or custom quote

Proteintech Guarantee

Filter: AllFCAffinity

FC experiment of human PBMCs using 98626-2-RR (same clone as 98626-2-PBS)
1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LTBR Rabbit RecAb (98626-2-RR, Clone:251739F2), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Cells were incubated with FC Receptor Block prior to staining. This data was developed using the same antibody clone with 98626-2-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LTBR Rabbit RecAb (98626-2-RR, Clone:251739F2), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Cells were incubated with FC Receptor Block prior to staining. This data was developed using the same antibody clone with 98626-2-PBS in a different storage buffer formulation.
FC experiment of human PBMCs using 98626-2-RR (same clone as 98626-2-PBS)
1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LTBR Rabbit RecAb (98626-2-RR, Clone:251739F2) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue),and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.Cells were incubated with FC Receptor Block prior to staining. This data was developed using the same antibody clone with 98626-2-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LTBR Rabbit RecAb (98626-2-RR, Clone:251739F2) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue),and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.Cells were incubated with FC Receptor Block prior to staining. This data was developed using the same antibody clone with 98626-2-PBS in a different storage buffer formulation.
FC experiment of HeLa using 98626-2-RR (same clone as 98626-2-PBS)
1x10^6 HeLa cells were surface stained with 0.25 ug Anti-Human LTBR Rabbit RecAb (98626-2-RR, Clone:251739F2) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were not fixed. This data was developed using the same antibody clone with 98626-2-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
Affinity of 98626-2-RR
Biolayer interferometry (BLl) kinetic assays of 98626-2-RR against Human LTBR were performed. The affinity constant is 2.39 nM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

Overview

Tested Applications
Product Information

Print datasheet

MSDS SDS

Product Information

98626-2-PBS targets LTBR in FC applications and shows reactivity with human samples.

Tested Reactivity	human
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	CatNo: Eg5126 Product name: Recombinant Human LTBR protein (rFc Tag) Source: mammalian cells-derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 31-227 aa of BC026262 Sequence: QAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLM Predict reactive species
Full Name	lymphotoxin beta receptor (TNFR superfamily, member 3)
Calculated Molecular Weight	435 aa, 47 kDa
GenBank Accession Number	BC026262
Gene Symbol	LTBR
Gene ID (NCBI)	4055
RRID	AB_3746225
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	P36941
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

Lymphotoxin-beta receptor (LTBR) is a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It can activate the NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA1-LTB2) (PMID: 24248355). LTBR is constitutively expressed on stromal cells and myeloid lineage cells but not on T or B lymphocytes, which may be a novel immune checkpoint of tumor-associated macrophages (PMID: 20603617; 39429877).