Anti-Mouse MAdCAM1 Rabbit Recombinant Antibody, PBS Only

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• Anti-Mouse MAdCAM1 Rabbit Recombinant Antibody, PBS Only (98444-1-PBS)

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  FC experiment of Transfected HEK-293T using 98444-1-RR (same clone as 98444-1-PBS)

  1x10^6 HEK-293T or MAdCAM1-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse MAdCAM1 Rabbit RecAb (98444-1-RR, Clone: 242902D6) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98444-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98444-1-RR (same clone as 98444-1-PBS)

  1x10^6 HEK-293T or MAdCAM1-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse MAdCAM1 Rabbit RecAb (98444-1-RR, Clone: 242902D6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98444-1-PBS in a different storage buffer formulation.

MAdCAM1 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98444-1-PBS

Clone No.242902D6

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

Adhesion molecule immunoglobulin-like domain-containing protein, MAdCAM-1

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Product Information

98444-1-PBS targets MAdCAM1 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2010

  Product name: Recombinant Mouse MAdCAM-1 protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 22-364 aa of NP_038619

  Sequence: QSFQVNPPESEVAVAMGTSLQITCSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQHSVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIPVLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGPCRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPMVEGWFQCRQDPGGQVTNLYVPGQVTPNSSS

• Full Name: mucosal vascular addressin cell adhesion molecule 1
• Calculated Molecular Weight: 44kDa
• GenBank Accession Number: NP_038619
• Gene Symbol: Madcam1
• Gene ID (NCBI): 17123
• RRID: AB_3746082
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Lymphocyte recirculation through different organs is thought to be regulated by adhesion molecules ("homing receptors") recognizing tissue-specific vascular addressins on endothelium (PMID: 7511642). The mucosal vascular addressin, MAdCAM1, is an immunoglobulin superfamily adhesion receptor for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria (PMID: 7687523). MAdCAM1 can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.