Product Information
24379-1-PBS targets METTL13 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag19355 Product name: Recombinant human METTL13 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 541-642 aa of BC029083 Sequence: QSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRI Predict reactive species |
| Full Name | methyltransferase like 13 |
| Calculated Molecular Weight | 699 aa, 79 kDa |
| Observed Molecular Weight | 72-78 kDa |
| GenBank Accession Number | BC029083 |
| Gene Symbol | METTL13 |
| Gene ID (NCBI) | 51603 |
| RRID | AB_3742110 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8N6R0 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Protein methyltransferase like 13 (METTL13), also called FEAT, is coded by gene METTL13, which is located at chromosome 1q24.3. Purified from rat livers in 2011 by a Japanese researcher, METTL13 was found to be abnormally overexpressed in several human cancers including lung cancer and to drive tumorigenesis in transgenic mice. A study indicated that METTL13 inhibits apoptosis of lung, breast and liver cancer cells and miR-16 can repress the expression of METTL13 by binding to its 3′-untranslated region. (PMID: 33985542)
