METTL7B Polyclonal antibody, PBS Only

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• METTL7B Polyclonal antibody, PBS Only (17001-1-PBS)

METTL7B Polyclonal Antibody for WB, IHC, ELISA

Cat No. 17001-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, ELISA

Synonyms

EC:2.1.1.9, methyltransferase like 7B, Methyltransferase-like protein 7B, Thiol S-methyltransferase METTL7B, Thiol S-methyltransferase TMT1B

• 

  WB analysis using 17001-1-AP (same clone as 17001-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 17001-1-AP (METTL7B antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17001-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse liver using 17001-1-AP (same clone as 17001-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 17001-1-AP (METTL7B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17001-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse liver using 17001-1-AP (same clone as 17001-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 17001-1-AP (METTL7B antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17001-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

17001-1-PBS targets METTL7B in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag10694

  Product name: Recombinant human METTL7B protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 39-244 aa of BC020509

  Sequence: MAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK

• Full Name: methyltransferase like 7B
• Calculated Molecular Weight: 244aa,28 kDa
• Observed Molecular Weight: 28 kDa
• GenBank Accession Number: BC020509
• Gene Symbol: METTL7B
• Gene ID (NCBI): 196410
• RRID: AB_2142199
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q6UX53
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

METTL7B is a membrane-associated small-molecule methyltransferase that catalyzes S-methylation of alkyl thiols, thereby linking thiol/sulfur metabolism, redox homeostasis, and cellular stress responses. By influencing antioxidant enzyme expression and detoxification pathways, METTL7B plays a pivotal role in tumor growth and drug resistance, particularly in lung adenocarcinoma. Its upregulation in multiple cancers and involvement in redox/thiol metabolism make it an emerging therapeutic target in oncology and possibly in metabolic/oxidative stress-related disease settings. (PMID: 40068772)