Anti-Human MICA/MICB (6D4)

MICA/MICB Monoclonal Antibody for FC

Host / Isotype

Mouse / Mouse IgG2a

Reactivity

Human and More (1)

Applications

WB,FC

Conjugate

Unconjugated

CloneNo.

6D4

Cat no : 65161-1-Ig

Synonyms

MICA, MICB



Tested Applications

Positive FC detected inHeLa cells

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 1 publications below

Product Information

65161-1-Ig targets MICA/MICB in WB,FC applications and shows reactivity with Human samples.

Tested Reactivity Human
Cited Reactivity human
Host / Isotype Mouse / Mouse IgG2a
Class Monoclonal
Type Antibody
Immunogen Transfected C1R cells expressing MICA
Full Name MHC class I polypeptide-related sequence A
Calculated molecular weight 383 aa, 43 kDa
GenBank accession numberBC016929
Gene symbol MICA
Gene ID (NCBI) 4276
Conjugate Unconjugated
Form Liquid
Purification Method Purified by protein-A affinity chromatography
Storage Buffer PBS with 0.1% sodium azide.
Storage ConditionsStore at 2-8°C.

Background Information

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). The monoclonal antibody 6D4 recognizes MICA and MICB.

Protocols

Product Specific Protocols
FC protocol for MICA/MICB antibody 65161-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Immunother

BCMA-targeting Bispecific Antibody That Simultaneously Stimulates NKG2D-enhanced Efficacy Against Multiple Myeloma.

Authors - Yang Wang