Product Information
88031-1-PBS targets MITD1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Ag10998 Product name: Recombinant human MITD1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-249 aa of BC018453 Sequence: MAKSGLRQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI Predict reactive species |
| Full Name | MIT, microtubule interacting and transport, domain containing 1 |
| Calculated Molecular Weight | 249 aa, 29 kDa |
| Observed Molecular Weight | 29 kDa |
| GenBank Accession Number | BC018453 |
| Gene Symbol | MITD1 |
| Gene ID (NCBI) | 129531 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q8WV92 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
MITD1 (Microtubule Interacting and Trafficking Domain Containing 1) has a molecular weight of approximately 29.3 kDa and consists of 249 amino acids. Functionally, MITD1 regulates ESCRT-III activity and is required for efficient abscission at the end of cytokinesis. It functions as a homodimer, with its N-terminal MIT domain binding to a subset of ESCRT-III subunits and its C-terminal unanticipated phospholipase D-like (PLD) domain binding to membranes. Depletion of MITD1 causes cytokinetic defects, including midbody destabilization and abscission failure. Beyond its role in cell division, MITD1 has recently been identified as a brain-specific interferon-inducible factor that inhibits flavivirus replication.
