Product Information
31550-1-PBS targets MOCS1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag35879 Product name: Recombinant human MOCS1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 90-290 aa of NM_001075098 Sequence: EEGVPLTPKANLLTTEEILTLARLFVKEGIDKIRLTGGEPLIRPDVVDIVAQLQRLEGLRTIGVTTNGINLARLLPQLQKAGLSAINISLDTLVPAKFEFIVRRKGFHKVMEGIHKAIELGYNPVKVNCVVMRGLNEDELLDFAALTEGLPLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTAK Predict reactive species |
| Full Name | molybdenum cofactor synthesis 1 |
| Calculated Molecular Weight | 70kDa |
| Observed Molecular Weight | 40-43 kDa |
| GenBank Accession Number | NM_001075098 |
| Gene Symbol | MOCS1 |
| Gene ID (NCBI) | 4337 |
| RRID | AB_3742448 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9NZB8 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
MOCS1 (Molybdenum cofactor synthesis 1), also known as MOCS1A, MOCS1B, MOCOD, plays a crucial role in the biosynthesis of molybdenum cofactor and molybdopterin, which are essential for the activity of several key enzymes involved in carbon, nitrogen, and sulfur metabolism. MOCS1 produces two functional proteins, MOCS1A and MOCS1B, which follow different translocation routes before mitochondrial matrix import for cPMP biosynthesis involving both proteins (PMID: 31996372). MOCS1 was tumor suppressor gene affecting survival positively, while the other genes were oncogenes whose high expression was associated with poor survival (PMID: 37120564). The MOCS1 protein exists multiple isoforms.
