MXRA5 Polyclonal antibody, PBS Only

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• MXRA5 Polyclonal antibody, PBS Only (25472-1-PBS)

• 

  WB analysis using 25472-1-AP (same clone as 25472-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25472-1-AP (MXRA5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 25472-1-AP (same clone as 25472-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

MXRA5 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 25472-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

Adlican

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Product Information

25472-1-PBS targets MXRA5 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: matrix-remodelling associated 5
• Calculated Molecular Weight: 312 kDa
• Observed Molecular Weight: 163 kDa, 312 kDa
• GenBank Accession Number: NM_015419
• Gene Symbol: MXRA5
• Gene ID (NCBI): 25878
• RRID: AB_2918088
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9NR99
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MXRA5, or adlican, is an adhesion proteoglycan involved in extracellular matrix (ECM) remodeling and cell-cell adhesion (PMID: 22696596). In kidney, MXRA5 has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli (PMID: 27599751). MXRA5 was identified as a novel biomarker in colorectal cancer, mainly located in the cytoplasm of CRC cells (PMID:23420087). Exome sequencing identified MXRA5 as a novel cancer gene mutated in non-small cell lung carcinoma (PMID: 22696596). MXRA5 was detected 163 kDa in human proximal tubular cells (PMID:27599751).