MCL1L-specific Polyclonal antibody
MCL1L-specific Polyclonal Antibody for IHC,ELISA
Host / Isotype
Rabbit / IgG
human, mouse, rat
Cat no : 15825-1-AP
Validation Data Gallery
|Positive IHC detected in
|human spleen tissue, human brain tissue, human breast cancer tissue, human cervical cancer tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human testis tissue, human tonsillitis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|IHC : 1:20-1:200
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
15825-1-AP targets MCL1L-specific in IHC,ELISA applications and shows reactivity with human, mouse, rat samples.
|human, mouse, rat
|Host / Isotype
|Rabbit / IgG
|myeloid cell leukemia sequence 1 (BCL2-related)
|Calculated molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to MCL1L isoform.