Recombinant Mouse APCDD1 protein (rFc Tag)

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• Recombinant Mouse APCDD1 protein (rFc Tag) (Eg2690)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2690

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Validation Data Gallery

• 

  Purity of Recombinant Mouse Apcdd1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse APCDD1 protein Leu27-Thr492 (Accession# Q3U128) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 494504
• Accession: Q3U128
• PredictedSize: 79.3 kDa
• SDS-PAGE: 80-90 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

APCDD1(adenomatosis polyposis coli down-regulated 1) is a membrane-bound glycoprotein conserved during vertebrate evolution that regulates important biological processes controlled by Wnt signaling. APCDD1 is a membrane-bound glycoprotein that is abundantly expressed in human HFs (hair follicles) and can interact in vitro with WNT3A and LRP5, two essential components of Wnt signaling. APCDD1 may be modified by glycosylation.

References:

1. Neupane S. (2015). Histochem Cell Biol. 144(4):377-87.
2. Shimomura Y. (2010). Nature. 15;464(7291):1043-7.