Recombinant Mouse CCL24/Eotaxin 2 protein (His Tag)

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• Recombinant Mouse CCL24/Eotaxin 2 protein (His Tag) (Eg0693)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Cat no : Eg0693

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Validation Data Gallery

• 

  Purity of Recombinant Mouse CCL24 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse CCL24 protein Val27-Val119 (Accession# Q9JKC0) with a His tag at the C-terminus.
• GeneID: 56221
• Accession: Q9JKC0
• PredictedSize: 11.4 kDa
• SDS-PAGE: 17-20 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CCL24, known as eotaxin-2, is a chemokine that promotes cell trafficking and regulates inflammatory and fibrotic activities mainly through the C-C motif chemokine receptor 3 (CCR3) complex. It is expressed by activated T cells, monocytes, epithelial and endothelial cells as well as by activated fibroblasts. CCL24 is considered a contributor to kinds of atopic disorders, parasitic infections and numerous systemic diseases. CCL24 is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line.

References:

1. Ann S Heiman. et al. (2005)J Interferon Cytokine Res. 25(2):82-91.
2. Nicola L Diny. et al. (2016) Eur J Immunol. 46(12): 2749-2760.
3. Petronela Ancuta. et al. (2006) J Immunol. 176(10): 5760-71.
4. Witold Owczarek. et al. (2010) Cytokine. 50(2):181-5.